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Target not currently curated in GtoImmuPdb

Target id: 518

Nomenclature: K2P6.1

Abbreviated Name: TWIK2

Family: Two-pore domain potassium channels (K2P)

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 313 19q13.2 KCNK6 potassium two pore domain channel subfamily K member 6 1,3
Mouse 4 2 313 7 B1 Kcnk6 potassium inwardly-rectifying channel, subfamily K, member 6
Rat 4 2 313 1q21 Kcnk6 potassium two pore domain channel subfamily K member 6
Previous and Unofficial Names Click here for help
TOSS | potassium channel subfamily K member 6 (TWIK-2) | potassium channel, two pore domain subfamily K, member 6 | potassium inwardly-rectifying channel
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics Click here for help

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Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
quinidine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Guide to Malaria Pharmacology Ligand Rn - - pIC50 < 1x10-4 - 2
pIC50 Conc range: < 1x10-4 M [2]
Ba2+ Click here for species-specific activity table Rn - - pIC50 1x10-5 - 1x10-4 - 2
pIC50 Conc range: 1x10-5 - 1x10-4 M [2]
Tissue Distribution Click here for help
Pancreas, placenta and heart
Species:  Human
Technique:  Northern Blot
References:  3
Species:  Mouse
Technique:  Northern Blot
References:  3
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. Displays time-dependent inactivation at depolarized potentials [2]. The rat variant has been reported to be widely expressed (including brain, lung, kidney, liver, spleen, heart, oesophagus, stomach, colon, skeletal muscle).


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1. Gray AT, Kindler CH, Sampson ER, Yost CS. (1999) Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. Cytogenet Cell Genet, 84 (3-4): 190-1. [PMID:10393428]

2. Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honoré E. (2000) TWIK-2, an inactivating 2P domain K+ channel. J Biol Chem, 275 (37): 28722-30. [PMID:10887187]

3. Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, Holmes D, Saganich M, Rudy B, Artman M, Coetzee WA. (1999) Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. FEBS Lett, 450 (3): 191-6. [PMID:10359073]


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