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K2P13.1

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Target not currently curated in GtoImmuPdb

Target id: 523

Nomenclature: K2P13.1

Abbreviated Name: THIK1

Family: Two P domain potassium channels

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 408 14q32.11 KCNK13 potassium two pore domain channel subfamily K member 13 3
Mouse 4 2 405 12 E Kcnk13 potassium channel, subfamily K, member 13
Rat 4 2 405 6q32 Kcnk13 potassium two pore domain channel subfamily K member 13
Previous and Unofficial Names Click here for help
THIK-1 | prdx1 | tandem pore domain halothane-inhibited potassium channel 1 | potassium channel, two pore domain subfamily K, member 13 | potassium channel
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins Click here for help
Heteromeric Pore-forming Subunits
Name References
K2P12.1 1
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Associated Protein Comments
Heterodimerization of K2P12 and K2P13 was recently reported in a heterologous expression system [1].

N-terminal endoplasmic retention signal has been reported [2,4] but no protein partners identified.
Functional Characteristics Click here for help
Background current

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
arachidonic acid Small molecule or natural product Ligand is endogenous in the given species Ligand has a PDB structure N/A - - - 1x10-3 - 1
Conc range: 1x10-3 M studied at ~5 µM [1]
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
halothane Small molecule or natural product Approved drug Click here for species-specific activity table Hs - - - - - 1
studied at ~5 mM [1]
Channel Blockers
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
Ba2+ N/A - - - - -
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. K2P13 like channels are found in the central nervous system of Aplysia californica.

References

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1. Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D. (2014) Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. J Biol Chem, 289 (41): 28202-12. [PMID:25148687]

2. Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F. (2013) Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. J Biol Chem, 288 (49): 35081-92. [PMID:24163367]

3. Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C. (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem, 276 (10): 7302-11. [PMID:11060316]

4. Renigunta V, Zou X, Kling S, Schlichthörl G, Daut J. (2014) Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflugers Arch, 466 (9): 1735-45. [PMID:24297522]

Contributors

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