Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	2	408	14q32.11	KCNK13	potassium two pore domain channel subfamily K member 13	4
Mouse	4	2	405	12 E	Kcnk13	potassium channel, subfamily K, member 13
Rat	4	2	405	6q32	Kcnk13	potassium two pore domain channel subfamily K member 13

Previous and Unofficial Names

THIK-1 | prdx1 | tandem pore domain halothane-inhibited potassium channel 1 | potassium channel, two pore domain subfamily K, member 13 | potassium channel

Database Links
Alphafold	Q9HB14 (Hs), Q8R1P5 (Mm), Q9ERS0 (Rn)
ChEMBL Target	CHEMBL4523461 (Hs)
Ensembl Gene	ENSG00000152315 (Hs), ENSMUSG00000045404 (Mm), ENSRNOG00000047363 (Rn)
Entrez Gene	56659 (Hs), 217826 (Mm), 64120 (Rn)
Human Protein Atlas	ENSG00000152315 (Hs)
KEGG Gene	hsa:56659 (Hs), mmu:217826 (Mm), rno:64120 (Rn)
OMIM	607367 (Hs)
Pharos	Q9HB14 (Hs)
RefSeq Nucleotide	NM_022054 (Hs), NM_146037 (Mm), NM_022293 (Rn)
RefSeq Protein	NP_071337 (Hs), NP_666149 (Mm), NP_071629 (Rn)
UniProtKB	Q9HB14 (Hs), Q8R1P5 (Mm), Q9ERS0 (Rn)
Wikipedia	KCNK13 (Hs)

Associated Proteins
Heteromeric Pore-forming Subunits Name References K2P12.1 2	Auxiliary Subunits Name References Not determined	Other Associated Proteins Name References Not determined
Associated Protein Comments
Heterodimerization of K2P12 and K2P13 was recently reported in a heterologous expression system [2]. N-terminal endoplasmic retention signal has been reported [3,5] but no protein partners identified.

Functional Characteristics
Background current

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference arachidonic acid N/A - - - 1x10-3 - 2 ⤷ Conc range: 1x10-3 M studied at ~5 µM [2]

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference CVN293 Mm Inhibition 7.6 pIC50 - - 1 ⤷ pIC50 7.6 (IC50 2.8x10-8 M) [1] Description: Dertermined in HEK cells overexpressing mouse kcnk13 CVN293 Hs Inhibition 7.3 pIC50 - - 1 ⤷ pIC50 7.3 (IC50 4.9x10-8 M) [1] Description: Determined in HEK cells overexpressing hKCNK13 halothane Hs - - - - - 2 ⤷ studied at ~5 mM [2]
View species-specific inhibitor tables

Channel Blockers
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference Ba2+ N/A - - - - - ⤷

General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. K2P13 like channels are found in the central nervous system of Aplysia californica.