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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 529 | 12p13.32 | KCNA6 | potassium voltage-gated channel subfamily A member 6 | 1,5 |
| Mouse | 6 | 1 | 529 | 6 61.72 cM | Kcna6 | potassium voltage-gated channel, shaker-related, subfamily, member 6 | 11 |
| Rat | 6 | 1 | 530 | 4q42 | Kcna6 | potassium voltage-gated channel subfamily A member 6 | 11 |
| Previous and Unofficial Names |
| HBK2 | RCK2 | potassium voltage-gated channel subfamily A member 6 | potassium voltage gated channel, shaker related subfamily, member 6 | potassium voltage-gated channel, shaker-related subfamily, member 6 | potassium channel, voltage gated shaker related subfamily A, member 6 | potassium voltage-gated channel, shaker-related, subfamily, member 6 | potassium voltage-gated channel |
| Database Links |
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| Alphafold | P17658 (Hs), Q61923 (Mm), P17659 (Rn) |
| ChEMBL Target | CHEMBL5279 (Hs), CHEMBL4105906 (Rn) |
| DrugBank Target | P17658 (Hs) |
| Ensembl Gene | ENSG00000151079 (Hs), ENSMUSG00000038077 (Mm), ENSRNOG00000052486 (Rn) |
| Entrez Gene | 3742 (Hs), 16494 (Mm), 64358 (Rn) |
| Human Protein Atlas | ENSG00000151079 (Hs) |
| KEGG Gene | hsa:3742 (Hs), mmu:16494 (Mm), rno:64358 (Rn) |
| OMIM | 176257 (Hs) |
| Pharos | P17658 (Hs) |
| RefSeq Nucleotide | NM_002235 (Hs), NM_013568 (Mm), NM_023954 (Rn) |
| RefSeq Protein | NP_002226 (Hs), NP_038596 (Mm), NP_076444 (Rn) |
| UniProtKB | P17658 (Hs), Q61923 (Mm), P17659 (Rn) |
| Wikipedia | KCNA6 (Hs) |
| Associated Proteins |
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| Functional Characteristics |
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| KV | |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Associated subunits (Human) |
| Kv β1 and Kv β2 |
Download all structure-activity data for this target as a CSV file 
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific channel blocker tables | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blocker Comments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| β-bungarotoxin (pIC50 6.7), 10-N-methylcarbamoyl-3, 7 -bis(dimethylamino)phenothiazine (pIC50 6.7), 4-AP (pIC50 6.7), p114a (pIC50 5.8) [5,18]. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||
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| Gene Expression and Pathophysiology
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| Biologically Significant Variant Comments |
| A total of 1034 SNPs have been identified in human KCNA6. For more information please see the entry on GeneCards. |
| General Comments |
| Kv1.6 may co-assemble with other Kv1 family members in heteromultimers. It cannot, however, co-assemble with members of other Kv families. It has an intronless coding region. The N-terminus of the protein contains an N-terminus inactivation prevention (NIP) domain [16] |
1. Albrecht B, Weber K, Pongs O. (1995) Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. Recept Channels, 3 (3): 213-20. [PMID:8821794]
2. Attali B, Wang N, Kolot A, Sobko A, Cherepanov V, Soliven B. (1997) Characterization of delayed rectifier Kv channels in oligodendrocytes and progenitor cells. J Neurosci, 17 (21): 8234-45. [PMID:9334399]
3. Dodson PD, Barker MC, Forsythe ID. (2002) Two heteromeric Kv1 potassium channels differentially regulate action potential firing. J Neurosci, 22 (16): 6953-61. [PMID:12177193]
4. Glazebrook PA, Ramirez AN, Schild JH, Shieh CC, Doan T, Wible BA, Kunze DL. (2002) Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons. J Physiol (Lond.), 541 (Pt 2): 467-82. [PMID:12042352]
5. Grupe A, Schröter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S, Pongs O. (1990) Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J, 9 (6): 1749-56. [PMID:2347305]
6. Imperial JS, Chen P, Sporning A, Terlau H, Daly NL, Craik DJ, Alewood PF, Olivera BM. (2008) Tyrosine-rich conopeptides affect voltage-gated K+ channels. J Biol Chem, 283 (34): 23026-32. [PMID:18505731]
7. Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA et al.. (1998) ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem, 273 (49): 32697-707. [PMID:9830012]
8. Koh SD, Ward SM, Dick GM, Epperson A, Bonner HP, Sanders KM, Horowitz B, Kenyon JL. (1999) Contribution of delayed rectifier potassium currents to the electrical activity of murine colonic smooth muscle. J Physiol (Lond.), 515 ( Pt 2): 475-87. [PMID:10050014]
9. Koschak A, Bugianesi RM, Mitterdorfer J, Kaczorowski GJ, Garcia ML, Knaus HG. (1998) Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem, 273 (5): 2639-44. [PMID:9446567]
10. Matus-Leibovitch N, Vogel Z, Ezra-Macabee V, Etkin S, Nevo I, Attali B. (1996) Chronic morphine administration enhances the expression of Kv1.5 and Kv1.6 voltage-gated K+ channels in rat spinal cord. Brain Res Mol Brain Res, 40 (2): 261-70. [PMID:8872310]
11. Migeon MB, Street VA, Demas VP, Tempel BL. (1992) Cloning, sequence and chromosomal localization of MK6, a murine potassium channel gene. Epilepsy Res Suppl, 9: 173-80; discussion 180-1. [PMID:1285906]
12. Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E. (1999) Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron, 24 (4): 1037-47. [PMID:10624965]
13. Racapé J, Lecoq A, Romi-Lebrun R, Liu J, Kohler M, Garcia ML, Ménez A, Gasparini S. (2002) Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain. J Biol Chem, 277 (6): 3886-93. [PMID:11707459]
14. Rasband MN, Trimmer JS, Peles E, Levinson SR, Shrager P. (1999) K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol, 28 (4-5): 319-31. [PMID:10739574]
15. Rhodes KJ, Strassle BW, Monaghan MM, Bekele-Arcuri Z, Matos MF, Trimmer JS. (1997) Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. J Neurosci, 17 (21): 8246-58. [PMID:9334400]
16. Roeper J, Sewing S, Zhang Y, Sommer T, Wanner SG, Pongs O. (1998) NIP domain prevents N-type inactivation in voltage-gated potassium channels. Nature, 391 (6665): 390-3. [PMID:9450755]
17. Smart SL, Bosma MM, Tempel BL. (1997) Identification of the delayed rectifier potassium channel, Kv1.6, in cultured astrocytes. Glia, 20 (2): 127-34. [PMID:9179597]
18. Swanson R, Marshall J, Smith JS, Williams JB, Boyle MB, Folander K, Luneau CJ, Antanavage J, Oliva C, Buhrow SA. (1990) Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron, 4 (6): 929-39. [PMID:2361015]
19. Wang J, Juhaszova M, Rubin LJ, Yuan XJ. (1997) Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells. J Clin Invest, 100 (9): 2347-53. [PMID:9410914]
20. Wang J, Weigand L, Wang W, Sylvester JT, Shimoda LA. (2005) Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery. Am J Physiol Lung Cell Mol Physiol, 288 (6): L1049-58. [PMID:15665041]
21. Yuan XJ, Wang J, Juhaszova M, Golovina VA, Rubin LJ. (1998) Molecular basis and function of voltage-gated K+ channels in pulmonary arterial smooth muscle cells. Am J Physiol, 274 (4 Pt 1): L621-35. [PMID:9575881]
