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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 511 | 1p13.3 | KCNA10 | potassium voltage-gated channel subfamily A member 10 | 6 |
| Mouse | 6 | 1 | 511 | 3 | Kcna10 | potassium voltage-gated channel, shaker-related subfamily, member 10 | |
| Rat | 6 | 1 | 511 | 2q34 | Kcna10 | potassium voltage-gated channel subfamily A member 10 | |
| Previous and Unofficial Names |
| kv1.10 | Kcn1 | cyclic GMP gated potassium channel | KCNA10 | potassium voltage-gated channel subfamily A member 10 | Kcna8 | potassium channel, voltage gated shaker related subfamily A, member 10 | potassium voltage-gated channel |
| Database Links |
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| Alphafold | Q16322 (Hs) |
| ChEMBL Target | CHEMBL2363001 (Hs) |
| DrugBank Target | Q16322 (Hs) |
| Ensembl Gene | ENSG00000143105 (Hs), ENSMUSG00000042861 (Mm), ENSRNOG00000050416 (Rn) |
| Entrez Gene | 3744 (Hs), 242151 (Mm), 295360 (Rn) |
| Human Protein Atlas | ENSG00000143105 (Hs) |
| KEGG Gene | hsa:3744 (Hs), mmu:242151 (Mm), rno:295360 (Rn) |
| OMIM | 602420 (Hs) |
| Pharos | Q16322 (Hs) |
| RefSeq Nucleotide | NM_005549 (Hs), NM_001074609 (Mm), NM_001191713 (Rn) |
| RefSeq Protein | NP_005540 (Hs), NP_001074609 (Mm), NP_001178642 (Rn) |
| UniProtKB | Q16322 (Hs) |
| Wikipedia | KCNA10 (Hs) |
| Associated Proteins |
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| Functional Characteristics |
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| KV | |
| Ion Selectivity and Conductance |
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| Ion Selectivity and Conductance Comments | ||||||
| K+/Na+ > 70:1; |
| Voltage Dependence |
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| Associated subunits (Human) |
| Kv β1 and Kv β2 |
Download all structure-activity data for this target as a CSV file 
| Activator Comments | ||
| cGMP acts as an activator in rabbit [9] |
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Biologically Significant Variant Comments |
| A total of 189 SNPs have been identified in human KCNA5. For more information please see the entry on GeneCards. |
| General Comments |
| Kv1.8 can co-assemble with other Kv1 family members, however it cannot do so with members of other Kv families. It has an intronless coding region, like many other members of the family (except Kv1.7) It is a member of the mammalian Shaker-related family. A null mutation leads to vestibular dysfunction [5]. |
1. Carlisle FA, Steel KP, Lewis MA. (2012) Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti. Gene Expr Patterns, 12 (5-6): 172-9. [PMID:22446089]
2. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 291 (5): L993-1004. [PMID:16815889]
3. Iwasa H, Kurabayashi M, Nagai R, Nakamura Y, Tanaka T. (2001) Genetic variations in five genes involved in the excitement of cardiomyocytes. J Hum Genet, 46 (9): 549-52. [PMID:11558906]
4. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. (2000) KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol Renal Physiol, 278 (6): F1013-21. [PMID:10836990]
5. Lee SI, Conrad T, Jones SM, Lagziel A, Starost MF, Belyantseva IA, Friedman TB, Morell RJ. (2013) A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction. Hear Res, 300: 1-9. [PMID:23528307]
6. Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV. (1997) Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics, 42 (1): 33-7. [PMID:9177773]
7. Tian S, Liu W, Wu Y, Rafi H, Segal AS, Desir GV. (2002) Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. Am J Physiol Renal Physiol, 283 (1): F142-9. [PMID:12060596]
8. Yao X, Liu Y, Tung F, Desir GV. (1996) Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel. Am J Physiol, 271 (1 Pt 2): F37-41. [PMID:8760241]
9. Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, Desir GV. (1995) Primary structure and functional expression of a cGMP-gated potassium channel. Proc Natl Acad Sci USA, 92 (25): 11711-5. [PMID:8524834]
10. Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. (2002) Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J Am Soc Nephrol, 13 (12): 2831-9. [PMID:12444201]
