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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 513 | 20q13.13 | KCNG1 | potassium voltage-gated channel modifier subfamily G member 1 | 8 |
| Mouse | 6 | 1 | 514 | 2 H3 | Kcng1 | potassium voltage-gated channel, subfamily G, member 1 | |
| Rat | 6 | 1 | 514 | 3q42 | Kcng1 | potassium voltage-gated channel modifier subfamily G member 1 | |
| Previous and Unofficial Names |
| K13 | KCNG1 | KH2 | potassium channel, voltage gated modifier subfamily G, member 1 | potassium channel, voltage-gated modifier subfamily G, member 1 | potassium voltage-gated channel |
| Database Links |
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| Alphafold | Q9UIX4 (Hs), A2BDX4 (Mm) |
| Ensembl Gene | ENSG00000026559 (Hs), ENSMUSG00000074575 (Mm), ENSRNOG00000054314 (Rn) |
| Entrez Gene | 3755 (Hs), 241794 (Mm), 296395 (Rn) |
| Human Protein Atlas | ENSG00000026559 (Hs) |
| KEGG Gene | hsa:3755 (Hs), mmu:241794 (Mm), rno:296395 (Rn) |
| OMIM | 603788 (Hs) |
| Pharos | Q9UIX4 (Hs) |
| RefSeq Nucleotide | NM_002237 (Hs), NM_001081134 (Mm), NM_001106545 (Rn) |
| RefSeq Protein | NP_002228 (Hs), NP_001074603 (Mm), NP_001100015 (Rn) |
| UniProtKB | Q9UIX4 (Hs), A2BDX4 (Mm) |
| Wikipedia | KCNG1 (Hs) |
| Associated Proteins |
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| Ion Selectivity and Conductance |
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| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Biologically Significant Variant Comments |
| A total of 457 SNPs have been identified in human KCNG1. Please see the entry on GeneCards for more information. This variant has questionable validity because it originates from a cancer cell line . |
| General Comments |
| Kv6.1 has no function on its own, but has modulatory actions on Kv2 channels. |
1. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC. (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res, 78 (6): 1083-9. [PMID:8635239]
2. Drewe JA, Verma S, Frech G, Joho RH. (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J Neurosci, 12 (2): 538-48. [PMID:1740690]
3. Kramer JW, Post MA, Brown AM, Kirsch GE. (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Am J Physiol, 274 (6 Pt 1): C1501-10. [PMID:9696692]
4. O'Connell DJ, Bauer MC, O'Brien J, Johnson WM, Divizio CA, O'Kane SL, Berggård T, Merino A, Akerfeldt KS, Linse S et al.. (2010) Integrated protein array screening and high throughput validation of 70 novel neural calmodulin-binding proteins. Mol Cell Proteomics, 9 (6): 1118-32. [PMID:20068228]
5. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. (2004) Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 287 (1): L226-38. [PMID:15047570]
6. Post MA, Kirsch GE, Brown AM. (1996) Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. FEBS Lett, 399 (1-2): 177-82. [PMID:8980147]
7. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem, 272 (39): 24371-9. [PMID:9305895]
8. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y. (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun, 241 (3): 675-81. [PMID:9434767]
9. Thorneloe KS, Nelson MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J Physiol (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]
10. Verma-Kurvari S, Border B, Joho RH. (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res Mol Brain Res, 46 (1-2): 54-62. [PMID:9191078]
11. Wulfsen I, Hauber HP, Schiemann D, Bauer CK, Schwarz JR. (2000) Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J Neuroendocrinol, 12 (3): 263-72. [PMID:10718922]
12. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes, 53 (3): 597-607. [PMID:14988243]
