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CCR6

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 63

Nomenclature: CCR6

Family: Chemokine receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 374 6q27 CCR6 C-C motif chemokine receptor 6 4,15,24
Mouse 7 367 17 A1 Ccr6 C-C motif chemokine receptor 6 21
Rat 7 366 1q12 Ccr6 C-C motif chemokine receptor 6
Previous and Unofficial Names Click here for help
CKR-L3 [24] | DCCR2 [19] | GPR-CY4 [4] | STRL22 [15] | DRY-6 | GPR29 | CD196
Database Links Click here for help
Specialist databases
GPCRdb ccr6_human (Hs), ccr6_mouse (Mm), q5bk58_rat (Rn)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
beta-defensin 4A {Sp: Human}
CCL20 {Sp: Human} , CCL20 {Sp: Mouse} , CCL20 {Sp: Rat}
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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]CCL20 (human) Peptide Ligand is labelled Ligand is radioactive Hs Full agonist ~10.0 pKd 9
pKd ~10.0 (Kd ~1x10-10 M) [9]
CCL20-SEAP(His)6 Peptide Hs Full agonist 9.0 pKd 4
pKd 9.0 [4]
CCL20 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Full agonist 7.9 – 8.5 pIC50 1,4,19
pIC50 7.9 – 8.5 [1,4,19]
Agonist Comments
Beta-defensin 4A (previously known as beta defensin 2) has been shown to be chemotactic for cells expressing CCR6 [23].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PF-07054894 Small molecule or natural product Immunopharmacology Ligand Hs Antagonist 8.2 pIC50 14
pIC50 8.2 (IC50 5.7x10-9 M) [14]
Description: Inhibition of CCL20-dependent human T cell chemotaxis in vitro
Immunopharmacology Comments
CCR6 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. CCR6 is expressed on a variety of immune cells including memory and regulatory T-cells [12,16], naïve and activated B cells [13], dendritic cells [22] and Th17 T-cells [3]. CCR6 is the main chemokine receptor of Th17 cells, which are implicated in many chronic inflammatory conditions. In addition, CCR6 and its only known ligand CCL20, are up-regulated in tissues of patients with chronic inflammatory conditions (e.g. psoriasis, arthritic conditions and inflammatory bowel disease) [5,10-11].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Calcium channel
References:  2
Tissue Distribution Click here for help
Monocytes, neutrophils, eosinophils, NK cells, T lymphocytes (CD4+, CD8+), B lymphocytes and dendritic cells.
Species:  Human
Technique:  immunocytochemistry.
References:  16
Primary adult astrocytes.
Species:  Human
Technique:  Flow cytometry.
References:  8
Tonsil B lymphocytes.
Species:  Human
Technique:  RT-PCR.
References:  7
Immature dendritic cells (Langerhans cells).
Species:  Human
Technique:  RT-PCR.
References:  6
T cells, CD34+ dendritic cells and lung dendritic cells.
Species:  Human
Technique:  RT-PCR.
References:  19
Spleen, lymph nodes, testes, small intestine, peripheral blood leukocytes.
T cells (both CD4+ and CD8+) and B cells.
Species:  Human
Technique:  Northern blotting.
References:  4
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of Ca2+ levels in peripheral blood leukocytes endogenously expressing the CCR6 receptor.
Species:  Human
Tissue:  Peripheral blood leukocytes.
Response measured:  Ca2+ influx.
References:  16
Measurement of chemotaxis of peripheral blood leukocytes endogenously the CCR6 receptor.
Species:  Human
Tissue:  Peripheral blood leukocytes.
Response measured:  Chemotaxis.
References:  16
Measurement of Ca2+ levels in HEK 293 cells transfected with the CCR6 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Ca2+ influx and IP3-mediated Ca2+ mobilisation from intracellular stores.
References:  19
Measurement of chemotaxis of HEK 293 cells transfected with the human CCR6 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Chemotaxis.
References:  23
Physiological Functions Click here for help
Chemotaxis.
Species:  Human
Tissue:  Langerhans cells.
References:  6
Physiological Consequences of Altering Gene Expression Click here for help
CCR6 knockout mice exhibit underdeveloped Peyer's patches and increased levels of T lymphocytes in the submucosal tissue of the gut. Following sensitisation by 2,4-dinitrofluorobenzene (DNBF), the knockout mice developed more severe and persistant inflammation, whereas knockout mice sensitised with allogeneic splenocytes displayed no inflammatory response.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  20
CCR6 knockout mice challenged with cockroach antigen (CA) showed reduced airway resistance, fewer eosinophils around the airway and decreased levels of Il-5 and IgE compared with CA-challenged wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  17
CCR6 receptor knockout mice show smaller Peyer's patches when compared to wild-type mice, containing reduced numbers of B and T cells. In addition, the knockout mice display a decreased number of M cells in the follicle-associated epithelia.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  18
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0008399 abnormal alpha-beta intraepithelial T cell morphology PMID: 12928364 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0002459 abnormal B cell physiology PMID: 17392163 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0008400 abnormal CD4-positive, alpha-beta intraepithelial T cell morphology PMID: 12928364 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002432 abnormal CD4-positive T cell morphology PMID: 19305396 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0005463 abnormal CD4-positive T cell physiology PMID: 11254677 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0005463 abnormal CD4-positive T cell physiology PMID: 19305396 
Ccr6tm1.1Jmf Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
B6.129-Ccr6
MGI:1333797  MP:0005463 abnormal CD4-positive T cell physiology PMID: 19662682 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology PMID: 12928364 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008722 abnormal chemokine secretion PMID: 17694574 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0000820 abnormal choroid plexus morphology PMID: 19305396 
Ccr6tm1.1Jmf Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
B6.129-Ccr6
MGI:1333797  MP:0002376 abnormal dendritic cell physiology PMID: 19662682 
Ccr6tm1Gma|Tg(Rorc-EGFP)1Ebe Ccr6tm1Gma/Ccr6tm1Gma,Tg(Rorc-EGFP)1Ebe/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MGI:3829389  MP:0002435 abnormal effector T cell morphology PMID: 18504307 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129
MGI:1333797  MP:0008198 abnormal follicular dendritic cell antigen presentation PMID: 16713979 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0008197 abnormal follicular dendritic cell physiology PMID: 16713979 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0002378 abnormal gut-associated lymphoid tissue morphology PMID: 16713979  17392163 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002378 abnormal gut-associated lymphoid tissue morphology PMID: 10843382 
Ccr6tm1.1Jmf Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
B6.129-Ccr6
MGI:1333797  MP:0008568 abnormal interleukin secretion PMID: 19662682 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008895 abnormal intraepithelial T cell number PMID: 10843382 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002619 abnormal lymphocyte morphology PMID: 19305396 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002451 abnormal macrophage physiology PMID: 17694574 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0006173 abnormal myeloid dendritic cell morphology PMID: 11254677 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0006173 abnormal myeloid dendritic cell morphology PMID: 17694574 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0003957 abnormal nitric oxide homeostasis PMID: 17694574 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008244 abnormal peritoneal macrophage morphology PMID: 17694574 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0002389 abnormal Peyer's patch follicle morphology PMID: 11254677 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002391 abnormal Peyer's patch germinal center morphology PMID: 10843382 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0000696 abnormal Peyer's patch morphology PMID: 11254677 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0000696 abnormal Peyer's patch morphology PMID: 17392163 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0000696 abnormal Peyer's patch morphology PMID: 10843382 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129
MGI:1333797  MP:0002392 abnormal Peyer's patch T cell area PMID: 16713979 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0002444 abnormal T cell physiology PMID: 12928364 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129
MGI:1333797  MP:0002444 abnormal T cell physiology PMID: 17615242 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0005017 decreased B cell number PMID: 17392163 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0005017 decreased B cell number PMID: 19305396 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008075 decreased CD4-positive T cell number PMID: 19305396 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008079 decreased CD8-positive T cell number PMID: 19305396 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0001807 decreased IgA level PMID: 10843382 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
B6.129-Ccr6
MGI:1333797  MP:0002492 decreased IgE level PMID: 11514610 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008498 decreased IgG3 level PMID: 10843382 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0001876 decreased inflammatory response PMID: 11254677 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0001876 decreased inflammatory response PMID: 17694574 
Ccr6tm1.1Jmf Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
B6.129-Ccr6
MGI:1333797  MP:0001876 decreased inflammatory response PMID: 19662682 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008661 decreased interleukin-10 secretion PMID: 17694574 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
B6.129S6-Ccr6
MGI:1333797  MP:0008664 decreased interleukin-12 secretion PMID: 18258848 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008664 decreased interleukin-12 secretion PMID: 17694574 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
B6.129S6-Ccr6
MGI:1333797  MP:0008700 decreased interleukin-4 secretion PMID: 18258848 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
B6.129-Ccr6
MGI:1333797  MP:0008703 decreased interleukin-5 secretion PMID: 11514610 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0000221 decreased leukocyte cell number PMID: 11254677 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0008133 decreased Peyer's patch number PMID: 17392163 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
B6.129S6-Ccr6
MGI:1333797  MP:0002411 decreased susceptibility to bacterial infection PMID: 18258848 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis PMID: 19305396 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
B6.129-Ccr6
MGI:1333797  MP:0005597 decreased susceptibility to type I hypersensitivity reaction PMID: 11514610 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
B6.129S6-Ccr6
MGI:1333797  MP:0008561 decreased tumor necrosis factor secretion PMID: 18258848 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0008561 decreased tumor necrosis factor secretion PMID: 17694574 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
B6.129-Ccr6
MGI:1333797  MP:0008723 impaired eosinophil recruitment PMID: 11514610 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0001829 increased activated T cell number PMID: 10843382 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0004977 increased B-1 B cell number PMID: 17694574 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0005091 increased double-positive T cell number PMID: 10843382 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002494 increased IgM level PMID: 10843382 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
B6.129S6-Ccr6
MGI:1333797  MP:0008566 increased interferon-gamma secretion PMID: 18258848 
Ccr6tm1Gma Ccr6tm1Gma/Ccr6tm1Gma
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1333797  MP:0000218 increased leukocyte cell number PMID: 11254677 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0002418 increased susceptibility to viral infection PMID: 10843382 
Ccr6tm1Lira Ccr6tm1Lira/Ccr6tm1Lira
involves: 129 * C57BL/6
MGI:1333797  MP:0005015 increased T cell number PMID: 10843382 
Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
involves: 129S6/SvEvTac * C57BL/6
MGI:1333797  MP:0005348 increased T cell proliferation PMID: 12928364 
Ccr6tm1Dgen Ccr6tm1Dgen/Ccr6tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:1333797  MP:0002169 no abnormal phenotype detected
Ccr6+|Ccr6tm1(EGFP)Irw Ccr6tm1(EGFP)Irw/Ccr6+
involves: 129S6/SvEvTac
MGI:1333797  MP:0002169 no abnormal phenotype detected PMID: 11754009 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Diffuse cutaneous systemic sclerosis
Orphanet: ORPHA220393
Disease:  Limited cutaneous systemic sclerosis
Orphanet: ORPHA220402

References

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1. Ai LS, Liao F. (2002) Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling. Biochemistry, 41 (26): 8332-41. [PMID:12081481]

2. Al-Aoukaty A, Rolstad B, Giaid A, Maghazachi AA. (1998) MIP-3alpha, MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells. Immunology, 95 (4): 618-24. [PMID:9893054]

3. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Filì L, Ferri S, Frosali F et al.. (2007) Phenotypic and functional features of human Th17 cells. J Exp Med, 204 (8): 1849-61. [PMID:17635957]

4. Baba M, Imai T, Nishimura M, Kakizaki M, Takagi S, Hieshima K, Nomiyama H, Yoshie O. (1997) Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem, 272 (23): 14893-8. [PMID:9169459]

5. Celis R, Planell N, Fernández-Sueiro JL, Sanmartí R, Ramírez J, González-Álvaro I, Pablos JL, Cañete JD. (2012) Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features. Arthritis Res Ther, 14 (2): R93. [PMID:22541888]

6. Charbonnier AS, Kohrgruber N, Kriehuber E, Stingl G, Rot A, Maurer D. (1999) Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. J Exp Med, 190 (12): 1755-68. [PMID:10601351]

7. Corcione A, Tortolina G, Bonecchi R, Battilana N, Taborelli G, Malavasi F, Sozzani S, Ottonello L, Dallegri F, Pistoia V. (2002) Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells. Int Immunol, 14: 883-892. [PMID:12147625]

8. Flynn G, Maru S, Loughlin J, Romero IA, Male D. (2003) Regulation of chemokine receptor expression in human microglia and astrocytes. J Neuroimmunol, 136 (1-2): 84-93. [PMID:12620646]

9. Greaves DR, Wang W, Dairaghi DJ, Dieu MC, Saint-Vis B, Franz-Bacon K, Rossi D, Caux C, McClanahan T, Gordon S et al.. (1997) CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med, 186 (6): 837-44. [PMID:9294138]

10. Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, Catron D, Buchanan ME, Müller A, deWaal Malefyt R et al.. (2000) Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol, 164 (12): 6621-32. [PMID:10843722]

11. Kaser A, Ludwiczek O, Holzmann S, Moschen AR, Weiss G, Enrich B, Graziadei I, Dunzendorfer S, Wiedermann CJ, Mürzl E et al.. (2004) Increased expression of CCL20 in human inflammatory bowel disease. J Clin Immunol, 24 (1): 74-85. [PMID:14997037]

12. Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rötzschke O, Falk K. (2005) CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood, 105 (7): 2877-86. [PMID:15613550]

13. Krzysiek R, Lefevre EA, Bernard J, Foussat A, Galanaud P, Louache F, Richard Y. (2000) Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells. Blood, 96 (7): 2338-45. [PMID:11001880]

14. Li W, Crouse KK, Alley J, Frisbie RK, Fish SC, Andreyeva TA, Reed LA, Thorn M, DiMaggio G, Donovan CB et al.. (2023) A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation. J Pharmacol Exp Ther, 386 (1): 80-92. [PMID:37142443]

15. Liao F, Lee HH, Farber JM. (1997) Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics, 40 (1): 175-80. [PMID:9070937]

16. Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM. (1999) CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol, 162 (1): 186-94. [PMID:9886385]

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