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2.1.1.- Protein arginine N-methyltransferases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Protein arginine N-methyltransferases (PRMT, EC 2.1.1.-) encompass histone arginine N-methyltransferases (PRMT4, PRMT7, EC 2.1.1.125) and myelin basic protein N-methyltransferases (PRMT7, EC 2.1.1.126). They are dimeric or tetrameric enzymes which use S-adenosyl methionine as a methyl donor, generating S-adenosylhomocysteine as a by-product. They generate both mono-methylated and di-methylated products; these may be symmetric (SDMA) or asymmetric (NG,NG-dimethyl-L-arginine) versions, where both guanidine nitrogens are monomethylated or one of the two is dimethylated, respectively.

Enzymes

1259
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PRMT1 (protein arginine methyltransferase 1 ) Show summary » More detailed page go icon to follow link

PRMT2 (protein arginine methyltransferase 2 ) Show summary »

PRMT3 (protein arginine methyltransferase 3) Show summary » More detailed page go icon to follow link

PRMT4 (coactivator associated arginine methyltransferase 1) Show summary » More detailed page go icon to follow link

PRMT5 (protein arginine methyltransferase 5 ) Show summary » More detailed page go icon to follow link

PRMT6 (protein arginine methyltransferase 6) Show summary » More detailed page go icon to follow link

PRMT7 (protein arginine methyltransferase 7 ) Show summary » More detailed page go icon to follow link

PRMT8 (protein arginine methyltransferase 8) Show summary »


Target Id 1259
Nomenclature protein arginine methyltransferase 8
Common abbreviation PRMT8
Previous and unofficial names Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | HRMT1L3 | HRMT1L4
Genes PRMT8 (Hs), Prmt8 (Mm), Prmt8 (Rn)
Ensembl ID ENSG00000111218 (Hs), ENSMUSG00000030350 (Mm), ENSRNOG00000053804 (Rn)
UniProtKB AC Q9NR22 (Hs), Q6PAK3 (Mm)
Inhibitors
MS049 pIC50 5.8 [14]
Sub/family-selective inhibitors
MS023 pKi 8.9 [6]

PRMT9 (F-box protein 11) Show summary »

PRMT10 (protein arginine methyltransferase 9) Show summary »

PRMT11 (F-box protein 10) Show summary »

References

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How to cite this family page

Database page citation:

2.1.1.- Protein arginine N-methyltransferases. Accessed on 27/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=254.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.