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Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.

Enzymes

1269
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GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »


Target Id 1269
Nomenclature S-Adenosylmethionine decarboxylase
Common abbreviation SAMDC
Previous and unofficial names S-adenosylmethionine decarboxylase 1 | Amd1a | Amd1b | S-Adenosylmethionine decarboxylase 1A | S-Adenosylmethionine decarboxylase 1B | SAMDC
Genes AMD1 (Hs), Amd1 (Mm), Amd1 (Rn)
Ensembl ID ENSG00000123505 (Hs), ENSMUSG00000075232 (Mm), ENSRNOG00000000585 (Rn)
UniProtKB AC P17707 (Hs), P31154 (Mm), P17708 (Rn)
EC number
4.1.1.50
Endogenous substrates
S-adenosyl methionine
Products
S-adenosyl-L-methioninamine
Cofactors
pyruvic acid
Selective inhibitors
sardomozide pIC50 8.0 [7]
Comment S-allylglycine is also an inhibitor of SAMDC [4].

References

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How to cite this family page

Database page citation:

Decarboxylases. Accessed on 29/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.