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Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.

Enzymes

1272
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GAD1 (Glutamic acid decarboxylase 1) C Show summary »


Target Id 1272
Nomenclature Glutamic acid decarboxylase 1
Common abbreviation GAD1
Previous and unofficial names GAD1 (GAD65) | Gad67 | GAD | GAD25 | GAD44 | GAD-67 | glutamate decarboxylase 1 | Glutamate decarboxylase 1 (brain) | glutamate decarboxylase 1 (brain, 67kDa)
Genes GAD1 (Hs), Gad1 (Mm), Gad1 (Rn)
Ensembl ID ENSG00000128683 (Hs), ENSMUSG00000070880 (Mm), ENSRNOG00000000007 (Rn)
UniProtKB AC Q99259 (Hs), P48318 (Mm), P18088 (Rn)
EC number
4.1.1.15 L-glutamic acid + H+ -> GABA + CO2
Endogenous substrates
L-glutamic acid
L-aspartic acid
Products
GABA
Cofactors
pyridoxal 5-phosphate
Selective inhibitors
s-allylglycine
Comment L-aspartic acid is a less rapidly metabolised substrate of mouse brain glutamic acid decarboxylase generating β-alanine [9]. Autoantibodies against GAD1 and GAD2 are elevated in type 1 diabetes mellitus and neurological disorders (see Further reading).

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »

References

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How to cite this family page

Database page citation:

Decarboxylases. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.