Top ▲

Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.


Click here for help

GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

Target Id 1273
Nomenclature Glutamic acid decarboxylase 2
Common abbreviation GAD2
Previous and unofficial names GAD2 (GAD67) | glutamate decarboxylase 2 (pancreatic islets and brain, 65kD) | glutamic acid decarboxylase 65 | GAD65 | glutamate decarboxylase 2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Genes GAD2 (Hs), Gad2 (Mm), Gad2 (Rn)
Ensembl ID ENSG00000136750 (Hs), ENSMUSG00000026787 (Mm), ENSRNOG00000018200 (Rn)
UniProtKB AC Q05329 (Hs), P48320 (Mm), Q05683 (Rn)
EC number L-glutamic acid + H+ -> GABA + CO2
Endogenous substrates
L-glutamic acid
L-aspartic acid
pyridoxal 5-phosphate
Selective inhibitors
Comment L-aspartic acid is a less rapidly metabolised substrate of mouse brain glutamic acid decarboxylase generating β-alanine [9]. Autoantibodies against GAD1 and GAD2 are elevated in type 1 diabetes mellitus and neurological disorders (see Further reading).

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »


Click here for help

Show »

How to cite this family page

Database page citation:

Decarboxylases. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.