Top ▲

Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.

Enzymes

1273
Click here for help

GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »


Target Id 1273
Nomenclature Glutamic acid decarboxylase 2
Common abbreviation GAD2
Previous and unofficial names GAD2 (GAD67) | glutamate decarboxylase 2 (pancreatic islets and brain, 65kD) | glutamic acid decarboxylase 65 | GAD65 | glutamate decarboxylase 2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Genes GAD2 (Hs), Gad2 (Mm), Gad2 (Rn)
Ensembl ID ENSG00000136750 (Hs), ENSMUSG00000026787 (Mm), ENSRNOG00000018200 (Rn)
UniProtKB AC Q05329 (Hs), P48320 (Mm), Q05683 (Rn)
EC number
4.1.1.15 L-glutamic acid + H+ -> GABA + CO2
Endogenous substrates
L-glutamic acid
L-aspartic acid
Products
GABA
Cofactors
pyridoxal 5-phosphate
Selective inhibitors
s-allylglycine
Comment L-aspartic acid is a less rapidly metabolised substrate of mouse brain glutamic acid decarboxylase generating β-alanine [9]. Autoantibodies against GAD1 and GAD2 are elevated in type 1 diabetes mellitus and neurological disorders (see Further reading).

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Decarboxylases. Accessed on 07/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.