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Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.

Enzymes

1274
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GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

HDC (Histidine decarboxylase) C Show summary »


Target Id 1274
Nomenclature Histidine decarboxylase
Common abbreviation HDC
Previous and unofficial names Hdc-a | Hdc-c | Hdc-e | Hdc-s
Genes HDC (Hs), Hdc (Mm), Hdc (Rn)
Ensembl ID ENSG00000140287 (Hs), ENSMUSG00000027360 (Mm), ENSRNOG00000010262 (Rn)
UniProtKB AC P19113 (Hs), P23738 (Mm), P16453 (Rn)
EC number
4.1.1.22
Endogenous substrates
L-histidine
Products
histamine
Cofactors
pyridoxal 5-phosphate
Selective inhibitors
AMA
FMH [3]

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »

References

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How to cite this family page

Database page citation:

Decarboxylases. Accessed on 18/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.