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Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.

Enzymes

1277
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GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »


Target Id 1277
Nomenclature Phosphatidylserine decarboxylase
Common abbreviation PSDC
Previous and unofficial names PISD
Genes PISD (Hs), Pisd (Mm), Pisd (Rn)
Ensembl ID ENSG00000241878 (Hs), ENSMUSG00000023452 (Mm), ENSRNOG00000018319 (Rn)
UniProtKB AC Q9UG56 (Hs), Q8BSF4 (Mm)
EC number
4.1.1.65
Endogenous substrates
phosphatidylserine
Products
phosphatidylethanolamine
Cofactors
pyruvic acid
Comment S-allylglycine is also an inhibitor of SAMDC [4].

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »

References

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How to cite this family page

Database page citation:

Decarboxylases. Accessed on 03/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.