vidupiprant   Click here for help

GtoPdb Ligand ID: 10169

Synonyms: AMG 853 | AMG-853 | AMG853 | compound 2 [PMID: 24900313]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Vidupiprant (AMG853) is a dual prostanoid DP1 and DP2 receptor antagonist that was developed for anti-asthmatic potential [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 130.18
Molecular weight 608.1
XLogP 6.8
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)Cc1cc(Cl)c(cc1F)Oc1ccc(cc1NS(=O)(=O)c1ccc(cc1Cl)C1CC1)C(=O)NC(C)(C)C
Isomeric SMILES OC(=O)Cc1cc(Cl)c(cc1F)Oc1ccc(cc1NS(=O)(=O)c1ccc(cc1Cl)C1CC1)C(=O)NC(C)(C)C
InChI InChI=1S/C28H27Cl2FN2O6S/c1-28(2,3)32-27(36)17-6-8-23(39-24-14-21(31)18(11-19(24)29)13-26(34)35)22(12-17)33-40(37,38)25-9-7-16(10-20(25)30)15-4-5-15/h6-12,14-15,33H,4-5,13H2,1-3H3,(H,32,36)(H,34,35)
InChI Key PFWVGKROPKKEDW-UHFFFAOYSA-N
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
DP2 receptor Hs Antagonist Antagonist 8.5 pIC50 - 2
pIC50 8.5 (IC50 3x10-9 M) [2]
DP1 receptor Hs Antagonist Antagonist 8.4 pIC50 - 2
pIC50 8.4 (IC50 4x10-9 M) [2]