Synonyms: AMG 853 | AMG-853 | AMG853 | compound 2 [PMID: 24900313]
Compound class:
Synthetic organic
Comment: Vidupiprant (AMG853) is a dual prostanoid DP1 and DP2 receptor antagonist that was developed for anti-asthmatic potential [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Immunopharmacology Comments |
Prostaglandin D2 produced by mast cells plays a key role in mediating the allergic reponses observed as asthma, allergic rhinitis, and atopic dermatitis, via activation of the DP1 and DP2 prostanoid receptors, making these GPCRs targets for pharmacological antagonism (inhbition). Vidupiprant was designed to antagonise both of these receptors [2]. |