SU5402   Click here for help

GtoPdb Ligand ID: 11743

Synonyms: compound 1 [PMID: 10602697] | SU-5402
PDB Ligand
Compound class: Synthetic organic
Comment: SU5402 is an inhibitor of the enzymatic activity of receptor tyrosine kinases, including kinase insert domain receptor (VEGFR-2), fibroblast growth factor receptor 1 (FGFR1) and platelet derived growth factor receptor beta (PDGFRβ) [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 82.19
Molecular weight 296.12
XLogP 1.64
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)CCc1c([nH]cc1C)/C=C/1\C(=O)Nc2c1cccc2
Isomeric SMILES Cc1c[nH]c(c1CCC(=O)O)/C=C\1/c2ccccc2NC1=O
InChI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 7.7 pIC50 - 1
pIC50 7.7 (IC50 2x10-8 M) [1]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 7.5 pIC50 - 1
pIC50 7.5 (IC50 3x10-8 M) [1]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 6.3 pIC50 - 1
pIC50 6.3 (IC50 5.1x10-7 M) [1]