Synonyms: PRAX-562 | PRAX562
Compound class:
Synthetic organic
Comment: Relutrigine (PRAX-562) is an orally active, clinical stage Nav1.8 channel inhibitor [1]. It has demonstrated anticonvulsant activity in preclinical evaluations.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
PRAX-562 inhibits the induced sodium current (INa) in HEK-293 cells expressing NaV1.6 (activated by ATX-II) or the persistently active SNCA8N1768D variant with IC50 values of 141 nM and 75 nM respectively [1]. |
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