Compound class:
Synthetic organic
Comment: Benapenem is a carbapenem (β-lactam) with broad-spectrum antibacterial activity [2]. It has advanced to clinical evaluation as an intravenous treatment for urinary tract infections.
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Bioactivity Comments |
Benapenem has broad-spectrum antibacterial activity, that is similar to other carbapenems, and demonstrates an in vitro MIC50 of < 1 μg/ml against most bacteria species tested [2]. It has in vitro activity against Extended Spectrum Beta-Lactamase (ESBL) producing Enterobacterales, including Escherichia coli and Klebsiella pneumoniae clinical isolates with an MIC90 of 0.25 μg/ml [1]. |