Synonyms: ATV-006 | ATV006 | compound 5c [PMID: 34450570] | GS-5245 | GS5245
Compound class:
Synthetic organic
Comment: Obeldesivir (GS-5245) is an investigational nucleoside antiviral compound [1]. It is an ester prodrug of the predominant remdesivir metabolite GS-441524. As an inhibitor of viral RNA-dependent RNA polymerase (RdRP) it is likely to have activity against a range of filoviruses, paramyxoviruses, and coronaviruses, including SARS-CoV-2.
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Bioactivity Comments |
Obeldesivir (5c [1]) inhibits SARS-CoV-2 replication by 99% in vitro (in Vero E6 cells), with an EC50 of 230 nM, and has high oral bioavailability in mice [1]. |
Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
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