afamelanotide

Ligand id: 1324

Name: afamelanotide

Structure and Physico-chemical Properties

2D Structure
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
MC3 receptor Hs Agonist Full agonist 8.9 pKi - 1
pKi 8.9 [1]
MC4 receptor Hs Agonist Full agonist 8.5 – 8.8 pKi - 1,7,9
pKi 8.5 – 8.8 [1,7,9]
MC1 receptor Hs Agonist Full agonist 10.0 pIC50 - 4,8
pIC50 10.0 [4,8]
MC5 receptor Hs Agonist Full agonist 9.0 pIC50 - 4
pIC50 9.0 [4]