ICI 204448

Ligand id: 1650

Name: ICI 204448

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 70.08
Molecular weight 464.13
XLogP 4.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
κ receptor Rn Agonist Full agonist 8.8 pKi - 1
pKi 8.8 [1]
κ receptor Mm Agonist Full agonist 8.2 pIC50 - 2
pIC50 8.2 [2]