bilobalide

Ligand id: 2366

Name: bilobalide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 119.36
Molecular weight 326.1
XLogP -0.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Glycine Receptor (All subtypes) N/A Subunit-specific Inhibition - - < 1x10-6 1
Conc range: < 1x10-6 M α2 > α1 > α2β > α1β [1]
glycine receptor α2 subunit Hs Antagonist Antagonist 5.1 pIC50 -
pIC50 5.1 (IC50 8x10-6 M)
glycine receptor α1 subunit Hs Antagonist Antagonist 4.7 pIC50 -
pIC50 4.7 (IC50 2x10-5 M)
glycine receptor β subunit Hs Antagonist Antagonist 3.7 – 4.3 pIC50 -
pIC50 4.3 (IC50 5x10-5 M) when co-expressed with the α2 subunit
pIC50 3.7 (IC50 2.04x10-4 M) when co-expressed with the α1 subunit
5-HT3A Hs Channel blocker - 3.3 pIC50 - 2
pIC50 3.3 (IC50 4.7x10-4 M) [2]
5-HT3AB Hs Channel blocker - 2.5 pIC50 - 3
pIC50 2.5 (IC50 3.1x10-3 M) [3]
Ligand mentioned in the following text fields