Ligand id: 2366

Name: bilobalide

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 119.36
Molecular weight 326.1
XLogP -0.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Glycine Receptor (All subtypes) N/A Subunit-specific Inhibition - - < 1x10-6 1
Conc range: < 1x10-6 M α2 > α1 > α2β > α1β [1]
glycine receptor α2 subunit Hs Antagonist Antagonist 5.1 pIC50 -
pIC50 5.1 (IC50 8x10-6 M)
glycine receptor α1 subunit Hs Antagonist Antagonist 4.7 pIC50 -
pIC50 4.7 (IC50 2x10-5 M)
glycine receptor β subunit Hs Antagonist Antagonist 3.7 – 4.3 pIC50 -
pIC50 4.3 (IC50 5x10-5 M) when co-expressed with the α2 subunit
pIC50 3.7 (IC50 2.04x10-4 M) when co-expressed with the α1 subunit
5-HT3A Hs Channel blocker - 3.3 pIC50 - 2
pIC50 3.3 (IC50 4.7x10-4 M) [2]
5-HT3AB Hs Channel blocker - 2.5 pIC50 - 3
pIC50 2.5 (IC50 3.1x10-3 M) [3]
Ligand mentioned in the following text fields