adenosine 5'-monophosphate

Ligand id: 2455

Name: adenosine 5'-monophosphate

Abbreviated name: AMP

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 5
Rotatable bonds 4
Topological polar surface area 195.88
Molecular weight 347.06
XLogP -3.08
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Natural/Endogenous Targets
Target
AMP kinase
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
Adenosine kinase
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Peroxisomal membrane protein
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPM4 Hs Gating inhibitor Antagonist 4.7 pIC50 - 2
pIC50 4.7 [2]
Voltage: 100.0 mV
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AMP kinase Hs Activator Activation 4.2 pEC50 - 1
pEC50 4.2 (EC50 6.1x10-5 M) [1]
Description: Activation of AMPK partially purified from HEK cells.
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference