Ligand id: 2634

Name: triiodothyronine

Abbreviated name: T3

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.78
Molecular weight 650.79
XLogP 2.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Thyroid hormone receptor-α
Thyroid hormone receptor-β
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
iodothyronine deiodinase 1
iodothyronine deiodinase 2
iodothyronine deiodinase 3
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Monocarboxylate transporter 8 1
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Thyroid hormone receptor-β Hs Agonist Agonist 10.1 pKd - 2
pKd 10.1 [2]
Thyroid hormone receptor-α Hs Agonist Agonist 10.0 pKd - 2
pKd 10.0 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields