Ligand id: 2659

Name: LY-465608

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 81.79
Molecular weight 457.19
XLogP 6.02
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at nuclear hormone receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Peroxisome proliferator-activated receptor-α Hs Agonist Agonist 6.8 pIC50 - 1-2
pIC50 6.8 [1-2]
Peroxisome proliferator-activated receptor-γ Hs Agonist Full agonist 6.3 pIC50 - 1
pIC50 6.3 [1]