LY-465608

Ligand id: 2659

Name: LY-465608

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 81.79
Molecular weight 457.19
XLogP 6.02
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Peroxisome proliferator-activated receptor-α Hs Agonist Agonist 6.8 pIC50 - 1-2
pIC50 6.8 [1-2]
Peroxisome proliferator-activated receptor-γ Hs Agonist Full agonist 6.3 pIC50 - 1
pIC50 6.3 [1]