felodipine   Click here for help

GtoPdb Ligand ID: 4190

Synonyms: Plandil® | Renedil®
Approved drug
felodipine is an approved drug (FDA (1991))
Compound class: Synthetic organic
Comment: Felodipine is a long-acting calcium channel blocker, and one of the dihydropyridine class of drugs.
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View more information in the IUPHAR Pharmacology Education Project: felodipine

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 64.63
Molecular weight 383.07
XLogP 5.08
No. Lipinski's rules broken 1
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Canonical SMILES CCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1Cl)Cl)C(=O)OC)C
Isomeric SMILES CCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1Cl)Cl)C(=O)OC)C
InChI InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
Bioactivity Comments
In addition to action as a voltage-gated L-type calcium channel blocker, ChEMBL list this drug as an antagonist of the mineralocorticoid receptor, NR3C2. However, we have been unable to find publicly available bioactivity data for this drug at any of its proposed molecular target(s), and have therefore not tagged a primary drug target.
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CFTR Hs Activator Potentiation 8.4 pKi - 1
pKi 8.4 (Ki 4x10-9 M) [1]
Targets where the ligand is described in the comment field
Target Comment