zidovudine   Click here for help

GtoPdb Ligand ID: 4825

Abbreviated name: AZT
Synonyms: 3'-azido-3'-deoxythymidine | Retrovir®
Approved drug PDB Ligand
zidovudine is an approved drug (FDA (1987))
Compound class: Synthetic organic
Comment: Zidovudine (AZT) is a nucleoside analogue reverse-transcriptase inhibitor (NRTI) class antiretroviral drug. It was the first antiretroviral for HIV to be approved by the US FDA, and it is now listed in the World Health Organization's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 96.68
Molecular weight 267.1
XLogP -0.12
No. Lipinski's rules broken 0
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Canonical SMILES OCC1OC(CC1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O
Isomeric SMILES OC[C@H]1O[C@H](C[C@@H]1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O
InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Sodium/nucleoside cotransporter 1
Solute carrier family 28 member 3
Equilibrative nucleoside transporter 2
Equilibrative nucleoside transporter 3 1