zidovudine   

GtoPdb Ligand ID: 4825

Abbreviated name: AZT
Synonyms: 3'-azido-3'-deoxythymidine | Retrovir®
zidovudine is an approved drug (FDA (1987))
Compound class: Synthetic organic
Comment: Zidovudine (AZT) is a nucleoside analogue reverse-transcriptase inhibitor (NRTI) class antiretroviral drug. It was the first antiretroviral for HIV to be approved by the US FDA, and it is now listed in the World Health Organization's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 96.68
Molecular weight 267.1
XLogP -0.12
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OCC1OC(CC1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O
Isomeric SMILES OC[C@H]1O[C@H](C[C@@H]1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O
InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI Key HBOMLICNUCNMMY-XLPZGREQSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1987))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
International Nonproprietary Names
INN number INN
6118 zidovudine
Synonyms
3'-azido-3'-deoxythymidine | Retrovir®
Comments
Zidovudine (AZT) is a nucleoside analogue reverse-transcriptase inhibitor (NRTI) class antiretroviral drug. It was the first antiretroviral for HIV to be approved by the US FDA, and it is now listed in the World Health Organization's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
Database Links
CAS Registry No. 30516-87-1 (source: Scifinder)
ChEBI CHEBI:10110
ChEMBL Ligand CHEMBL129
DrugBank Ligand DB00495
DrugCentral Ligand 2861
GtoPdb PubChem SID 178101527
Immunopaedia Search zidovudine
PubChem CID 35370
RCSB PDB Ligand AZZ
Search Google for chemical match using the InChIKey HBOMLICNUCNMMY-XLPZGREQSA-N
Search Google for chemicals with the same backbone HBOMLICNUCNMMY
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Search UniChem for chemical match using the InChIKey HBOMLICNUCNMMY-XLPZGREQSA-N
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Wikipedia Zidovudine

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Tocris
Azidothymidine
Cat. No. 4150