IFN-α2   Click here for help

GtoPdb Ligand ID: 4960

Synonyms: IFN-alpha-2 | interferon alpha-2 | Roferon A®
Approved drug Immunopharmacology Ligand
IFN-α2 is an approved drug (FDA (1989))
Comment: IFN-α2 is a type I IFN. The sequence of the recombinant peptide used clinically and known as interferon alfa-2a, is identical to that of human IFN-α2. Interferon alfa-2a has anti-viral, immunomodulatory and antineoplastic actions.
Pegylated IFN alfa 2a is on the World Health Organization's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
Species: Human
Bioactivity Comments
IFN-α2 binds the IFN-α/β receptor (IFNAR), a dimeric receptor that consists of protein chains encoded by the IFNAR1 and IFNAR2 genes, and induces expression of proteins containing ISRE or GAS transcription elements.
Natural/Endogenous Targets
Target
Interferon-α/β receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interferon-α/β receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
rontalizumab Peptide Hs Antibody Binding 10.7 pKd - 3
pKd 10.7 (Kd 1.8x10-11 M) [3]
sifalimumab Peptide Hs Antibody Binding 10.0 pKd - 4
pKd 10.0 (Kd 1x10-10 M) [4]