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Synonyms: STO 609 | STO-609
Compound class: Synthetic organic
Comment: STO609 is a selective and cell-permeable inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinases CaMKK1 and CaMKK2 . The compound has been assessed in preclinical studies.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Selectivity at enzymes|
|Key to terms and symbols||Click column headers to sort|
|Targets where the ligand is described in the comment field|
|Calmodulin-dependent kinase II||
Camodulin-dependent kinase II is a homo- or heterotromultimeric holoenzyme made up of 8 to 12 subunit chains.
STO609 is an inhibitor of calmodulin kinase kinase , an upstream activator of calmodulin-dependent kinase.