Compound class:
Synthetic organic
Comment: TOFA inhibits acetyl-CoA carboxylase-induced fatty acid synthesis in human MCF-7 cells [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
We have mapped TOFA to both ACC1 and ACC2 as the assay in human MCF-7 cells will depend on the isozyme(s) expressed in these cells [1]. The IC50 value in the table below is calculated by using the IC50 of 4µg/ml provided in [1]. |
Selectivity at enzymes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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