NU-7026   Click here for help

GtoPdb Ligand ID: 5959

Synonyms: DNA-PK inhibitor II | LY-293646 | NU 7026 | NU7026
Compound class: Synthetic organic
Comment: NU-7026 is a potent and selective, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) [5].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 42.68
Molecular weight 281.11
XLogP 4.29
No. Lipinski's rules broken 0
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Canonical SMILES O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1
Isomeric SMILES O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1
InChI InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
Bioactivity Comments
NU-7026 is reported to act as a radio- and chemo-sensitizer in several human tumour cell lines in vitro [9-10].
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
protein kinase, DNA-activated, catalytic subunit Primary target of this compound Hs Inhibitor Inhibition 6.6 pIC50 - 3
pIC50 6.6 (IC50 2.3x10-7 M) [3]