NU-7026   Click here for help

GtoPdb Ligand ID: 5959

Synonyms: DNA-PK inhibitor II | LY-293646 | NU 7026 | NU7026
Compound class: Synthetic organic
Comment: NU-7026 is a potent and selective, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) [5].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 42.68
Molecular weight 281.11
XLogP 4.29
No. Lipinski's rules broken 0
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Canonical SMILES O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1
Isomeric SMILES O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1
InChI InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 54.8 55.0 13.0
polo like kinase 3 Plk3/PLK3 Hs Inhibitor Inhibition 64.0 99.0 68.0
polo like kinase 1 Plk1/PLK1 Hs Inhibitor Inhibition 68.4 56.0 11.0
casein kinase 2, alpha 1 polypeptide subunit CK2/CK2a Hs Inhibitor Inhibition 70.9 18.0 -1.0
mitogen-activated protein kinase 10 JNK3/JNK3 Hs Inhibitor Inhibition 73.8 98.0 70.0
muscle associated receptor tyrosine kinase MuSK/MUSK Hs Inhibitor Inhibition 75.6 100.0 87.0
casein kinase 2, alpha prime polypeptide subunit CK2α2/CK2a2 Hs Inhibitor Inhibition 78.6 56.0 5.0
Pim-2 proto-oncogene, serine/threonine kinase Pim-2/PIM2 Hs Inhibitor Inhibition 78.8 87.0 45.0
dual specificity tyrosine phosphorylation regulated kinase 1A nd/DYRK1(DYRK1A) Hs Inhibitor Inhibition 79.0
CDC like kinase 3 CLK3/CLK3 Hs Inhibitor Inhibition 81.1 91.0 112.0
Displaying the top 10 targets  View all targets in screen »