NU-7026   Click here for help

GtoPdb Ligand ID: 5959

Synonyms: DNA-PK inhibitor II | LY-293646 | NU 7026 | NU7026
Compound class: Synthetic organic
Comment: NU-7026 is a potent and selective, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) [5].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 42.68
Molecular weight 281.11
XLogP 4.29
No. Lipinski's rules broken 0
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Canonical SMILES O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1
Isomeric SMILES O=c1cc(oc2c1ccc1c2cccc1)N1CCOCC1
InChI InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
No information available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
DNA-dependent protein kinase (DNA-PK) activity is essential for repair of DNA double-strand breaks [7]. Inhibition of DNA-PK sensitises cells to chemo- or radio-therapy agents [4,6], leading to increased DNA damage being induced by these types of cancer therapies. DNA-PK is a member of the phosphatidylinositol (PI) 3-kinase related kinase (PIKK) family involved in the signalling of cellular stress responses, which also includes the mammalian proteins ATM, ATR, mTOR and hSMG1 [4,8]. NU-7026 is 60-fold selective for DNA-PK over other PIKK family members.