TWS119

Ligand id: 5980

Name: TWS119

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 97.05
Molecular weight 318.11
XLogP 3.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
The source of the GSK-3β used for enzyme inhibition experiments in [3] is unclear. We have linked the IC50 to the human protein, but it may be mouse.
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
glycogen synthase kinase 3 beta Hs Inhibitor Inhibition 7.5 pIC50 - 3
pIC50 7.5 (IC50 3x10-8 M) [3]