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Synonyms: GSK inhibitor XII | GSK-3beta inhibitor XII | TWS-119
Compound class: Synthetic organic
Comment: The discovery of this compound as a glycogen synthase kinase-3β (GSK-3β) inhibitor is described in .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Mechanism Of Action and Pharmacodynamic Effects|
|GSK-3 negatively regulates several aspects of insulin signalling, and upregulated GSK-3 activity may be involved in the development of insulin resistance in type 2 diabetes [4,7] and in neurodegenerative disease [2,6,8]. GSK-3 inhibitors have therefore become the focus of intense drug discovery efforts.
TWS119 is reported to be involved in the induction of mammalian neurogenesis in embryonic stem cells in vitro, via inhibition of GSK-3β .