Ligand id: 5980

Name: TWS119

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 97.05
Molecular weight 318.11
XLogP 3.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
GSK-3 negatively regulates several aspects of insulin signalling, and upregulated GSK-3 activity may be involved in the development of insulin resistance in type 2 diabetes [4,7] and in neurodegenerative disease [2,6,8]. GSK-3 inhibitors have therefore become the focus of intense drug discovery efforts.
TWS119 is reported to be involved in the induction of mammalian neurogenesis in embryonic stem cells in vitro, via inhibition of GSK-3β [3].