GtoPdb Ligand ID: 5980

Synonyms: GSK inhibitor XII | GSK-3beta inhibitor XII | TWS-119
Compound class: Synthetic organic
Comment: The discovery of this compound as a glycogen synthase kinase-3β (GSK-3β) inhibitor is described in [3].
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 97.05
Molecular weight 318.11
XLogP 3.55
No. Lipinski's rules broken 0
Canonical SMILES Oc1cccc(c1)Oc1ncnc2c1cc([nH]2)c1cccc(c1)N
Isomeric SMILES Oc1cccc(c1)Oc1ncnc2c1cc([nH]2)c1cccc(c1)N
InChI InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
No information available.
Mechanism Of Action and Pharmacodynamic Effects
GSK-3 negatively regulates several aspects of insulin signalling, and upregulated GSK-3 activity may be involved in the development of insulin resistance in type 2 diabetes [4,7] and in neurodegenerative disease [2,6,8]. GSK-3 inhibitors have therefore become the focus of intense drug discovery efforts.
TWS119 is reported to be involved in the induction of mammalian neurogenesis in embryonic stem cells in vitro, via inhibition of GSK-3β [3].