mubritinib

Ligand id: 6011

Name: mubritinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 11
Topological polar surface area 65.97
Molecular weight 468.18
XLogP 5.37
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Hs Inhibitor Inhibition 8.2 pIC50 - 3
pIC50 8.2 (IC50 6x10-9 M) [3]
Description: Measuring tyrosine phosphorylation of HER2 in human bladder cancer cell lineT24.