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Synonyms: SKI 2 | SKI-II
Compound class: Synthetic organic
Comment: The discovery of this selective sphingosine kinase inhibitor is described in , where it is called compound II.
The above article cites  for the creation of the human sphingosine kinase protein used in their kinase assay. BLAST searches using the accession numbers in this article indicate the kinase assay was performed using the SPHK1 isozyme. SKI II exhibits some selectivity toward SK2 as a kinase inhibitor (Ki for SK2 = 7.9 μM vs. SK1 = 16 μM) . It is a more powerful promoter of SK1-degradation than of SK2-degradation .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Off-target inhibition of dihydroceramide desaturase-1 (DEGS1) by SKI II is primarily responsible for the compound's antiproliferative effects.|
|Selectivity at enzymes|
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