Ligand id: 6043

Name: SU11652

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.23
Molecular weight 414.18
XLogP 3.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 8.5 pIC50 - 4
pIC50 8.5 (IC50 3x10-9 M) [4]
KIT proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 8.0 pIC50 - 2
pIC50 8.0 (IC50 1x10-8 M) [2]
kinase insert domain receptor Hs Inhibitor Inhibition 7.6 pIC50 - 4
pIC50 7.6 (IC50 2.7x10-8 M) [4]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 6.8 pIC50 - 4
pIC50 6.8 (IC50 1.7x10-7 M) [4]