Abbreviated name: CA
Synonyms: cholate | Cholbam® | Kolbam® | Orphacol&Reg;
cholic acid is an approved drug (EMA (2013), FDA (2015))
Compound class:
Metabolite
Comment: Cholic acid is a primary bile acid. Along with chenodeoxycholic acid, it is one of the two major bile acids synthesized from cholesterol in the liver.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Natural/Endogenous Targets | |||
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Transporters Moving this Compound Across a Lipid Membrane | ||||||||||||
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Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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Selectivity at nuclear hormone receptors | ||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Potency order of endogenous ligands at GPBA receptor | lithocholic acid > deoxycholic acid > chenodeoxycholic acid, cholic acid | 2-3 |
Substrates at Sodium/bile acid and sulphated solute cotransporter 2 | glycodeoxycholic acid > glycoursodeoxycholic acid, glycochenodeoxycholic acid > taurocholic acid > cholic acid | 1 |
Endogenous substrates at Sodium/bile acid and sulphated solute cotransporter 1 | tauroursodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid > glycocholic acid > cholic acid | 4 |