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Abbreviated name: CA
Synonyms: cholate | Cholbam® | Kolbam® | Orphacol&Reg;
cholic acid is an approved drug (EMA (2013), FDA (2015))
Compound class: Metabolite or derivative
Comment: Cholic acid is a primary bile acid. Along with chenodeoxycholic acid, it is one of the two major bile acids synthesized from cholesterol in the liver.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|The EMA and FDA have approved cholic acid for the treatment of rare bile acid synthesis disorders in pediatric and adult patients. These disorders include those arising from defects in a single enzyme, and peroxisomal disorders including Zellweger spectrum disorders.
|Mechanism Of Action and Pharmacodynamic Effects
|In patients with defects in cholic acid synthesis due to functional enzyme deficiency, supplementation with cholic acid can help ensure correct levels of bile flow and aid absorption of fats and fat-soluable vitamins.
For extended ADME data see the following:
European Medicines Agency (EMA)