[D-Phe6,β-Ala11,Phe13,Nle14]bombesin-(6-14)   

GtoPdb Ligand ID: 632

Synonyms: [D-Phe6,β-Ala11,Phe13,Nle14]bombesin(6-14)
Comment: Synthetic analogue of bombesin
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
BB3 receptor Rn Agonist Full agonist 9.0 pKi - 2
pKi 9.0 (Ki 1x10-9 M) [2]
BB3 receptor Mm Agonist Full agonist 8.8 pKi - 2
pKi 8.8 (Ki 1.5x10-9 M) [2]
BB1 receptor Hs Agonist Full agonist 7.8 – 9.7 pKi - 2-3
pKi 7.8 – 9.7 [2-3]
BB3 receptor Hs Agonist Full agonist 8.1 – 8.4 pKi - 1
pKi 8.1 – 8.4 (Ki 8.9x10-9 – 4.2x10-9 M) [1]
BB2 receptor Hs Agonist Full agonist 7.8 – 8.0 pKi - 2
pKi 7.8 – 8.0 (Ki 1.5x10-8 – 1x10-8 M) [2]
BB2 receptor Hs Agonist Full agonist 10.1 – 10.3 pIC50 - 3
pIC50 10.1 – 10.3 (IC50 8.5x10-11 – 4.8x10-11 M) [3]
BB1 receptor Hs Agonist Full agonist 9.5 – 9.7 pIC50 - 3
pIC50 9.5 – 9.7 (IC50 3.2x10-10 – 2.1x10-10 M) [3]
Ligand mentioned in the following text fields