Synonyms: WX-671
Compound class:
Synthetic organic
Comment: Upamostat (WX-671) is an oral serine protease inhibitor prodrug. Its principal molecular target is plasminogen activator, urokinase (uPA; PLAU) [2]. The uPA system plays an important role in tumour invasion and metastasis. The active substance is WX-UK1.
|
|
Bioactivity Comments |
The active metabolite of upamostat, WX-UK1, inhibits plasmin directly and indirectly (through inhibition of uPA-mediated plasminogen activation) and this leaads to a significant reduction in primary tumour growth and metastasis in preclinical models [1,5]. |
Selectivity at enzymes | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|