belatacept   Click here for help

GtoPdb Ligand ID: 6892

Synonyms: BMS-224818 | LEA29Y | Nulojix®
Approved drug Immunopharmacology Ligand
belatacept is an approved drug (FDA (2011), EMA (2011))
Compound class: Antibody
Comment: A recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). CTLA-4 is essential for T-cell co-activation.
Belatecept differs from abatacept by only 2 amino acids.
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Bioactivity Comments
Belatacept binds to human CD86 with an IC50 of 0.102µg/mL and to CD80 with an IC50 of 0.009µg/mL [1].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD80 Primary target of this compound Hs Inhibitor Inhibition - - - 1
[1]
Description: IC50= 0.009µg/mL
CD86 Primary target of this compound Hs Inhibitor Inhibition - - - 1
[1]
Description: IC50= 0.120µg/mL