zonisamide   Click here for help

GtoPdb Ligand ID: 7047

Synonyms: AD-810 | CI-912 | PD-110843 | Zonegran®
Approved drug PDB Ligand
zonisamide is an approved drug (FDA (2000), EMA (2005))
Compound class: Synthetic organic
Comment: Zonisamide is a sulfonamide anticonvulsant.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 94.57
Molecular weight 212.03
XLogP 0.51
No. Lipinski's rules broken 0
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Canonical SMILES NS(=O)(=O)Cc1noc2c1cccc2
Isomeric SMILES NS(=O)(=O)Cc1noc2c1cccc2
InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
Bioactivity Comments
As the precise MMOA for this drug is unclear we have not tagged a primary drug target.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
carbonic anhydrase 1 Hs Inhibitor Inhibition 7.3 pKi - 1
pKi 7.3 (Ki 5.6x10-8 M) [1]
carbonic anhydrase 7 Hs Inhibitor Inhibition 6.9 pKi - 1
pKi 6.9 (Ki 1.17x10-7 M) [1]
carbonic anhydrase 12 Hs Inhibitor Inhibition 5.0 pKi - 1
pKi 5.0 (Ki 1.1x10-5 M) [1]