oxaprozin

Ligand id: 7252

Name: oxaprozin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 63.33
Molecular weight 293.11
XLogP 3.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
COX-1 Hs Inhibitor Inhibition 5.7 pIC50 - 1
pIC50 5.7 (IC50 2.2x10-6 M) [1]
epoxide hydrolase 2 Hs Inhibitor Inhibition 5.3 pIC50 - 2
pIC50 5.3 (IC50 5x10-6 M) [2]
Description: Inhibition of sEH's phosphatase activity in vitro using bacterially-expressed recombinant N-terminal domain of sEH.
COX-2 Hs Inhibitor Inhibition 4.4 pIC50 - 1
pIC50 4.4 (IC50 3.6x10-5 M) [1]