Synonyms: AGN-PC-0031SD | ARN-2966
Compound class:
Synthetic organic
Comment: 2-PMAP is an investigational compound for Alzheimer's disease (AD). A recent study has demonstrated that this compound crosses the blood-brain barrier and reduces levels of full-length amyloid precursor protein (APP) and amyloid beta (Aβ) deposition in the brains of AD model mice without causing significant toxicity [1]. This is accompanied by reduced Aβ pathology and rescue of memory deficit in AD model mice via an inhibitory effect on mRNA translation. This compound may exist as a tautomer with PubChem CID 68604369.
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Bioactivity Comments |
In CHO APP751SW cells ( a cellular model of AD), 2-PMAP lowers the steady-state APP level and inhibits Aβx-40 and Aβx-42 production in a dose-dependent manner, with a minimum EC50 ≤ 0.5μM [1]. |