Synonyms: AGN-PC-0031SD | ARN-2966
Compound class:
Synthetic organic
Comment: 2-PMAP is an investigational compound for Alzheimer's disease (AD). A recent study has demonstrated that this compound crosses the blood-brain barrier and reduces levels of full-length amyloid precursor protein (APP) and amyloid beta (Aβ) deposition in the brains of AD model mice without causing significant toxicity [1]. This is accompanied by reduced Aβ pathology and rescue of memory deficit in AD model mice via an inhibitory effect on mRNA translation. This compound may exist as a tautomer with PubChem CID 68604369.
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References |
1. Asuni AA, Guridi M, Pankiewicz JE, Sanchez S, Sadowski MJ. (2014)
Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol, 75 (5): 684-99. [PMID:24687915] |