Ligand id: 7556

Name: perospirone

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 84.99
Molecular weight 426.21
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
D4 receptor Hs Antagonist Antagonist 10.1 pKi - 2
pKi 10.1 (Ki 9x10-11 M) [2]
D3 receptor Hs Antagonist Antagonist 9.6 pKi - 3
pKi 9.6 (Ki 2.8x10-10 M) [3]
D2 receptor Hs Antagonist Antagonist 9.2 pKi - 1
pKi 9.2 (Ki 6x10-10 M) [1]
5-HT2A receptor Rn Antagonist Antagonist 4.7 pKi - 1
pKi 4.7 (Ki 1.8x10-5 M) [1]