CCL5   Click here for help

GtoPdb Ligand ID: 758

Synonyms: eosinophil chemotactic cytokine [EoCP] | regulated upon activation normal T cell expressed and secreted (RANTES)
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL5 (also known as RANTES- an acronym for regulated on activation, normal T cell expressed and secreted) is a CC family chemokine, that has HIV suppressive activity, as do the related CD8+ T cell chemokines CCL3 and CCL4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
CCR1
CCR3
CCR5
CXCR3
GPR75
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR5 Ligand is endogenous in the given species Hs Agonist Full agonist 9.2 – 9.7 pKi - 1,7-8
⤷ pKi 9.2 – 9.7 [1,7-8]
CCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 8.5 – 9.3 pKi - 3
⤷ pKi 8.5 – 9.3 [3]
CCR1 Ligand is endogenous in the given species Hs Agonist Full agonist 6.8 – 8.2 pKi - 2,4
⤷ pKi 6.8 – 8.2 [2,4]
CXCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 6.4 pKi - 11
⤷ pKi 6.4 [11]
GPR75 Ligand is endogenous in the given species Hs Agonist Full agonist 9.6 pEC50 - 5
⤷ pEC50 9.6 (EC50 2.6x10-10 M) [5]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Endogenous ligands at ACKR1 CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (CXCL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583)
Endogenous agonists at ACKR2 CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626)
Targets where the ligand is described in the comment field
Target Comment
GPR75 CCL5 (CCL5, P13501) was reported to be an agonist of GPR75 [5], but the pairing could not be repeated in an arrestin assay [10].