CCL5   Click here for help

GtoPdb Ligand ID: 758

Synonyms: eosinophil chemotactic cytokine [EoCP] | regulated upon activation normal T cell expressed and secreted (RANTES)
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL5 (also known as RANTES- an acronym for regulated on activation, normal T cell expressed and secreted) is a CC family chemokine, that has HIV suppressive activity, as do the related CD8+ T cell chemokines CCL3 and CCL4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms Click here for help
eosinophil chemotactic cytokine [EoCP] | regulated upon activation normal T cell expressed and secreted (RANTES)
Medical Relevance
Many diseases have been associated to certain RANTES polymorphisms. For further information see GeneRIFs
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CCL5 C-C motif chemokine ligand 5 Human chemokine (C-C motif) ligand 5 beta-chemokine RANTES, chemokine (C-C motif) ligand 5, D17S136E, MGC17164, RANTES, regulated upon activation, normally T-expressed, and presumably secreted, SCYA5, SISd, SIS-delta, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5, T-cell specific protein p288, T-cell specific RANTES protein, TCP228
Database Links Click here for help
Specialist databases
GPCRdb Ligand CCL5
Other databases
Ensembl Gene ENSG00000161570 (Hs)
Entrez Gene 6352 (Hs)
GtoPdb PubChem SID 135651690
Human Protein Atlas ENSG00000161570 (Hs)
OMIM 187011
RefSeq Protein NP_002976
UniProtKB P13501 (Hs)
Wikipedia CCL5 (Hs)